| Navan Town Cosmos FC | | | | |
01/07/2021  3- 0  |
| Navan Town Cosmos FC |
11/07/2021 1- 3 MDL |
| BYE |
| | |
| | 23/08/2021 2- 4  Waters Lane |
12/07/2021 8- 3  Waters Lane |
| |
| |
| Ballyjamesduff AFC – PB |
| | OMP United |
| OMP United | 05/09/2021 2- 5  |
01/07/2021 3- 0 |
| OMP United |
26/07/2021 4- 2  St Marys Park |
| BYE |
| | OMP United |
| Athboy Celtic FC | |
01/07/2021 3- 0 |
| Athboy Celtic FC |
| |
| BYE |
| | Trim Celtic AFC |
| Trim Celtic AFC | 02/10/2021 4- 1 |
01/07/2021 3- 0 |
| Trim Celtic AFC |
11/07/2021 6- 1  Tully Park |
| BYE |
| | Trim Celtic AFC |
| Parkceltic Summerhill | 23/08/2021 3- 0 Tully Park |
01/07/2021 3- 0 |
| Parkceltic Summerhill |
| |
| BYE |
| | Trim Celtic AFC |
| Kells Celtic Youths FC | |
01/07/2021 3- 0 |
| Kells Celtic Youths FC |
11/07/2021 3- 1 The Grange |
| BYE |
| | Kells Celtic Youths FC |
| Ballyjamesduff AFC – PA | |
01/07/2021 3- 0 |
| Ballyjamesduff AFC – PA |
| |
| BYE |
| |
| Drogheda United FC |
01/07/2021  3- 0 |
| Drogheda United FC |
11/07/2021 2- 1 Marley Lane |
| BYE |
| | Drogheda United FC |
| | 23/08/2021 1- 6 Marley Lane |
01/07/2021 3- 0 |
| |
| |
| BYE |
| | |
| Walshestown FC | 05/09/2021 4- 3  |
01/07/2021 3- 0 |
| Walshestown FC |
26/07/2021 2- 5 Walshestown JFC |
| BYE |
| | |
| | |
01/07/2021 0 Waters Lane |
| |
| |
| BYE |
| | |
| Torro United FC | |
01/07/2021 3- 0 |
| Torro United FC |
11/07/2021 4- 3  Powderly Park |
| BYE |
| | Torro United FC |
| Enfield Celtic FC | 23/08/2021 0- 5 Powderly Park |
01/07/2021 3- 0 |
| Enfield Celtic FC |
| |
| BYE |
| | Johnstown FC |
| Johnstown FC | |
01/07/2021 3- 0 |
| Johnstown FC |
26/07/2021 4- 1 |
| BYE |
| | Johnstown FC |
| Borora Juniors AFC | |
12/07/2021 1- 3 |
| Albion Rovers FC |
| |
| Albion Rovers FC |
